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个人信息Personal Information
教授
博士生导师
硕士生导师
性别：女
毕业院校：大连理工大学
学位：博士
所在单位：生物工程学院
学科：生物化工. 生物工程与技术. 药物工程
办公地点：生物楼512
联系方式：wangjingyun67@dlut.edu.cn
电子邮箱：wangjingyun67@dlut.edu.cn
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Transcellular delivery of messenger RNA payloads by a cationic supramolecular MOF platform
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论文类型：期刊论文
发表时间：2018-10-14
发表刊物：CHEMICAL COMMUNICATIONS
收录刊物：PubMed、SCIE
卷号：54
期号：80
页面范围：11304-11307
ISSN号：1359-7345
摘要：A supramolecular catiomer with a metal-organic framework (MOF) motif was developed to manufacture messenger RNA (mRNA) assemblies. In contrast to the linear catiomer, the dendritic MOF catiomer appeared to markedly improve the colloidal stability of the mRNA assemblies, particularly affording substantial protection to the mRNA payloads from enzymatic degradation, eventually conducing to appreciable mRNA transfection activities at the targeted cells.