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个人信息Personal Information
教授
博士生导师
硕士生导师
性别：女
毕业院校：大连理工大学
学位：博士
所在单位：生物工程学院
学科：生物化工. 生物工程与技术. 药物工程
办公地点：生物楼512
联系方式：wangjingyun67@dlut.edu.cn
电子邮箱：wangjingyun67@dlut.edu.cn
An Effective Minor Groove Binder as a Red Fluorescent Marker for Live-Cell DNA Imaging and Quantification
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论文类型：期刊论文
发表时间：2011-04-26
发表刊物：ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
收录刊物：Scopus、SCIE、EI、PubMed
卷号：50
期号：18
页面范围：4180-4183
ISSN号：1433-7851
关键字：cell cycle; DNA; fluorescent probes; imaging agents; nucleus staining
摘要：Seeing red: DEAB-TO-3 shows a large fluorescence enhancement upon binding to native DNA and a distinct selectivity for double-stranded DNA over total RNA. As a red fluorescent live-cell-permeant DNA minor groove binder, DEAB-TO-3 is promising for highly sensitive DNA detection in vitro and nucleus-specific imaging and DNA quantification in vivo (see picture). Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.