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个人信息Personal Information
教授
博士生导师
硕士生导师
性别：女
毕业院校：大连理工大学
学位：博士
所在单位：生物工程学院
学科：生物化工. 生物工程与技术. 药物工程
办公地点：生物楼512
联系方式：wangjingyun67@dlut.edu.cn
电子邮箱：wangjingyun67@dlut.edu.cn
A Hg(2+) fluorescent chemosensor without interference from anions and Hg(2+)-imaging in living cells
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论文类型：期刊论文
发表时间：2009-10-12
发表刊物：SENSORS AND ACTUATORS B-CHEMICAL
收录刊物：SCIE、EI、Scopus
卷号：142
期号：1
页面范围：191-196
ISSN号：0925-4005
关键字：Fluorescence; Chemosensor; Imaging; Mercury ion; Living cells; Anions
摘要：A fluorescent chemosensor, B2, for Hg(2+) containing a BODIPY fluorophore and carboxyl-thiol metal-bonding moieties was described. B2 exhibits selective fluorescence enhancement (123-fold) toward Hg(2+) over other metal ions. Especially, the fluorescence enhancement was unaffected by anions existing in environment and organism. B2 shows high sensitivity to Hg(2+) in a concentration of ppb range with detection limit of 77 nM. B2-ester, the membrane-permeable ethyl ester, is able to be hydrolyzed to B2 in vivo, and successfully applied to image intracellular Hg(2+) in living cells. (C) 2009 Elsevier B. V. All rights reserved.