个人信息Personal Information
教授
博士生导师
硕士生导师
任职 : 精细化工国家重点实验室主任,教育部智能材料化工前沿科学中心执行主任,大连理工大学膜科学与技术研究开发中心主任
性别:女
毕业院校:中国科学院大连化物所
学位:博士
所在单位:化工学院
学科:化学工程. 膜科学与技术. 生物医学工程
联系方式:hgaohong@dlut.edu.cn
电子邮箱:hgaohong@dlut.edu.cn
Chitosan-hydrophobic alginate nanocomposites stabilized pH-triggered Pickering emulsion for drug controlled-release
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论文类型:期刊论文
发表时间:2021-02-02
发表刊物:INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
卷号:162
页面范围:1888-1896
ISSN号:0141-8130
关键字:Hydrophobic alginate; Chitosan; Pickering emulsion; Drug release; Ibuprofen
摘要:Alginate or chitosan microparticles as drug loading system performed pH-responsiveness and biocompatibility, yet with the burst-release and limited encapsulation. In order to improve the performance, herein, Pickering emulsion of chitosan-hydrophobic alginate nanocomposite (HSA-CS NCs) as the bio-stabilizer, was proposed as the drug-loading vehicle. Integrating the merits of HSA-CS and Pickering emulsion, such drug carrier of emulsion performed pH-response and biocompatibility from HSA-CS, and high loading capacity and rigid layer from Pickering emulsion, so as for the manipulated release behavior. With thorough investigation, via the various pH-response of HSA-CS nanocomposite in the continuous simulated gastrointestinal fluid, Pickering emulsion gradually released the loading drug (ibuprofen) out, performing the pH-triggered controlled-release behavior. Ibuprofen-loaded Pickering emulsions (30 mg/mL) released nearly none in SGF for 3 h, whereas in SIF, performed constant release in initial 5 h and continuous-release of 88.37% ibuprofen in 24 h with no drug-burst and high loading capacity, promisingly as the pH-responsive vehicle for drug delivery in oral route. (C) 2020 Elsevier B.V. All rights reserved.